http://boxerhockey.fireball20xl.com/ is about a fictional sport called, well, boxerhockey. Well drawn and very funny, though slow on updates sometimes.
http://www.amazingsuperpowers.com/ goes against what you expect to happen. P.S., hovering over the comic gives you a funny line and there's also a secret comic by hovering your mouse a bit right from the upper right corner. Updates Mondays and Thursdays.
http://buttersafe.com/ has cute, quick comics. Updates every few days.